1-Ethynyl-2-fluorobenzene → HCID 58168357, compound

HRID 1029221Notes

Reaction equation

HRID 1029221 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[F:25])#[CH:18]>>[F:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:17]#[C:18][C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2

Participants

3

Reactant 2

HCID 6433581-Ethynyl-2-fluorobenzeneHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168357HCID 58168357, compoundYield 75%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 160 using 83 (100 mg, 0.43 mmol) and 1-ethynyl-2-fluorobenzene (0.07 mL, 0.65 mmol) to provide 259 (101 mg, 75% yield) as a tan solid. LC-MS (M+H=315 obsd.=315).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-0f69c78a58df4c889fb654088dd1ce9c
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

Loading…