HRID1029238

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID44603462

未命名化合物

结构：CN(C)CCNC(=O)c1ccc2c(=O)[nH]c3nccc(Cl)c3c2c1

HCID69810673

未命名化合物

PRODUCTS

生成物

结构：CN(C)CCNC(=O)c1ccc2c(=O)[nH]c3nccc(Nc4ccc(NC(=O)c5ccc(F)cc5C(F)(F)F)cc4)c3c2c1

HCID44206389

未命名化合物

收率 50%

PROCEDURE

实验过程

The title compound was synthesized according to the procedure described for the preparation of Example 267 using 296 (40 mg, 0.12 mmol), and N-(4-aminophenyl)-4-fluoro-2-(trifluoromethyl)benzamide (36 mg, 0.12 mmol) to provide 297 (35 mg, 50% yield) as a solid. LC-MS (M+H=607, obsd.=607).

WORKUP

后处理

customThe title compound was synthesized

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e5d4e2cf153f4565b593f32fa5ddc68e
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08735584B2
来源说明: uspto-grants-2014_05

反应 SMILES

Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[C:15]([C:17]([NH:19][CH2:20][CH2:21][N:22]([CH3:24])[CH3:23])=[O:18])[CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:45])[C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][C:35]=2[C:41]([F:44])([F:43])[F:42])=[CH:28][CH:27]=1>>[CH3:23][N:22]([CH3:24])[CH2:21][CH2:20][NH:19][C:17]([C:15]1[CH:14]=[CH:13][C:5]2[C:6](=[O:12])[NH:7][C:8]3[C:3]([C:4]=2[CH:16]=1)=[C:2]([NH:25][C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:45])[C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][C:35]=2[C:41]([F:44])([F:42])[F:43])=[CH:28][CH:27]=1)[CH:11]=[CH:10][N:9]=3)=[O:18]