HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-Aminophenyl)-4-fluoro-2-trifluoromethyl-benzamide → N-(2-(Dimethylamino)ethyl)-1-(4-(4-fluoro-2-(trifluoromethyl)benzamido)phenyl amino)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-9-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-Aminophenyl)-4-fluoro-2-trifluoromethyl-benzamide | HCID 44603462 | — |
| Reactant | 1-Chloro-N-(2-(dimethylamino)ethyl)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-9-carboxamide | HCID 69810673 | — |
| Product | N-(2-(Dimethylamino)ethyl)-1-(4-(4-fluoro-2-(trifluoromethyl)benzamido)phenyl amino)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-9-carboxamide | HCID 44206389 | 50% |
Reaction Steps
The title compound was synthesized according to the procedure described for the preparation of Example 267 using 296 (40 mg, 0.12 mmol), and N-(4-aminophenyl)-4-fluoro-2-(trifluoromethyl)benzamide (36 mg, 0.12 mmol) to provide 297 (35 mg, 50% yield) as a solid. LC-MS (M+H=607, obsd.=607).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-e5d4e2cf153f4565b593f32fa5ddc68e |
| Source note | uspto-grants-2014_05 |