Dimethylformamide → 5-[(3-amino-1-methyl-1H-indazol-6-yl)oxy]-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one

HRID 102924Notes

Reaction equation

HRID 102924 reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[Cl:1][c:2]1[cH:3][cH:4][n:5][c:6]2[c:11]1[CH2:10][N:9]([CH2:12][c:13]1[cH:14][cH:15][c:16]([O:19][CH3:20])[cH:17][cH:18]1)[C:8](=[O:21])[NH:7]2.[Cs+:38].[Cs+:39].[NH2:22][c:23]1[n:24][n:25]([CH3:33])[c:26]2[cH:27][c:28]([OH:32])[cH:29][cH:30][c:31]12.[O:40]=[CH:41][N:42]([CH3:43])[CH3:44]>>[c:2]1([O:32][c:28]2[cH:27][c:26]3[n:25]([CH3:33])[n:24][c:23]([NH2:22])[c:31]3[cH:30][cH:29]2)[cH:3][cH:4][n:5][c:6]2[c:11]1[CH2:10][N:9]([CH2:12][c:13]1[cH:14][cH:15][c:16]([O:19][CH3:20])[cH:17][cH:18]1)[C:8](=[O:21])[NH:7]2

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 669262915-chloro-3-[(4-methoxyphenyl)methyl]-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-2-oneHCID 1357424603-amino-1-methyl-1H-indazol-6-ol

Product 1

HCID 704971855-[(3-amino-1-methyl-1H-indazol-6-yl)oxy]-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one

Sources & evidence

ORD record
ord-57815a34d33f48d4aa4490e7864ab978
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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