4-Chloro-3-iodopyridin-2-amine → HCID 58168188, compound

HRID 1029265Notes

Reaction equation

HRID 1029265 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1I.[F:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[C:13]([C:20](OC)=[O:21])[CH:12]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:3]=1[C:14]1[CH:15]=[CH:16][C:11]([F:10])=[CH:12][C:13]=1[C:20](=[O:21])[NH:8]2

Participants

3

Reactant 2

HCID 229365964-Chloro-3-iodopyridin-2-amineHCID 44717309[4-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid

Product 1

HCID 58168188HCID 58168188, compoundYield 21.3%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 1 using 4-chloro-3-iodopyridin-2-amine (1.20 g, 4.72 mmol) and 4-fluoro-2-methoxycarbonylphenylboronic acid (1.03 g, 5.19 mmol) to provide 411 (250 mg, 21% yield) as a solid. LC-MS (M+H=249, obsd.=249).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-4033339ca4df4d8ea4d17875c6c61ff1
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

Loading…