HCID 15780326, compound → HCID 19037524, compound

HRID 1029434Notes

Reaction equation

HRID 1029434 reaction equation
[Cl:1]C(NC([N:7]1[CH2:12][CH2:11][CH:10]([N:13]2[CH2:26][CH2:25][C:16]3[N:17]([CH3:24])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=4[C:15]=3[C:14]2=[O:27])[CH2:9][CH2:8]1)=[O:6])C>CO>[OH2:6].[ClH:1].[ClH:1].[CH3:24][N:17]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=2[C:15]2[C:14](=[O:27])[N:13]([CH:10]3[CH2:11][CH2:12][NH:7][CH2:8][CH2:9]3)[CH2:26][CH2:25][C:16]1=2

Participants

3

Reactant 1

HCID 15780326HCID 15780326, compound

Product 1

HCID 19037524HCID 19037524, compoundYield 69.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-[1-(α-Chloroethylcarbamoyl)-4-piperidinyl]-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one (0.300 g) was dissolved in anhydrous methanol (6 ml), and the solution was heated under reflux for 4 hrs. The reaction mixture was evaporated, and the residue was recrystallized from absolute ethanol to afford 0.10 g (50%) of product.

Workup

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 4 hrs
  3. customThe reaction mixture was evaporated
  4. customthe residue was recrystallized from absolute ethanol

Sources & evidence

ORD record
ord-5ccaa1a0a242495e8048d2c9197c89c0
Source dataset
uspto-grants-1992_04
Patent number
US05102889

Reaction notes

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