HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 86745633, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 4-Oxocyclohexanecarboxylic acid | HCID 192730 | — |
| Reactant | HCID 19900451 | HCID 19900451 | — |
| Product | HCID 86745633 | HCID 86745633 | — |
Reaction Steps
The procedure is as in Example 1, but starting with 3-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (9.9 g) in anhydrous dimethylformamide (100 cc), 4-oxocyclohexanecarboxylic acid (4.25 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (4.6 g). After recrystallization in acetonitrile, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 4-oxocyclohexanecarboxylate (8.5 g), m.p. 203° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05102890 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-1084efbeb45649559c8a6e042a90b8c3 |
| Source note | uspto-grants-1992_04 |