反应详情

The procedure is as in Example 1, but starting with 3-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (9.9 g) in anhydrous dimethylformamide (100 cc), 4-oxocyclohexanecarboxylic acid (4.25 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (4.6 g). After recrystallization in acetonitrile, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 4-oxocyclohexanecarboxylate (8.5 g), m.p. 203° C., is obtained.

1. customAfter recrystallization in acetonitrile