反应详情

The procedure is as in Example 7, but starting with 5-hydroxy-6-(7-chloro-1,8-naphthyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine (6.3 g) in methylene chloride (80 cc), triethylamine (5.05 g), isobutyryl chloride (4.25 g) and 4-dimethylaminopyridine (50 mg). The solid obtained is washed with tetrahydrofuran. 6-(7-Chloro-1,8-naphthyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl isobutyrate (2.3 g), m.p. 260°-262° C., is thereby obtained.

1. customThe solid obtained
2. washis washed with tetrahydrofuran