HCID 178439966, compound → HCID 178439984, compound

HRID 1029570Notes

Reaction equation

HRID 1029570 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([CH2:29][CH2:30][CH3:31])[N:6]2[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:24]2[NH:28][N:27]=[N:26][N:25]=2)=[CH:14][CH:13]=1>C(O)C.[Pd]>[CH2:29]([C:5]1[N:6]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[NH:28][N:27]=[N:26][N:25]=3)=[CH:14][CH:13]=2)[C:7]2[C:3]([N:4]=1)=[CH:2][N:10]=[CH:9][N:8]=2)[CH2:30][CH3:31]

Participants

4

Reactant 1

HCID 178439966HCID 178439966, compound

Product 1

HCID 178439984HCID 178439984, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6-Chloro-8-propyl-9-(2'-(tetrazol-5-yl)biphen-4-yl)methylpurine (0.030 g) was dissolved in ethanol (2 ml) and was stirred under an atmosphere of hydrogen in presence of Pd-C(10%) (0.01 g) for 24 hours. The catalyst was filtered off and the filtrate was evaporated to dryness giving the pure desired product as a glass like solid (0.020 g). NMR (CD3OD): δ1.0 (t, 3H, J=7.4 Hz), 1.8 (m, 2H), 2.88 (t, 2H, J=7.4 Hz), 5.56 (s, 2H), 7.1-7.34 (m, 5H), 7.45-7.7 (m, 4H), 8.90 (s, 1H), 8.98 (s, 1H). FAB-MS: m/e 397 (M+H). Analysis calculated for C22H20N8 : C, 66.00; H, 5.00; N, 28.00. Found: C, 65.57; H, 5.34; N, 27.67.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-d5ee3cc5fb324de3ba713b43a92ece1c
Source dataset
uspto-grants-1992_04
Patent number
US05102880

Reaction notes

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