HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1029632Generated: October 30, 2026
Water → (S)-3-benzoyloxy-1-t-butoxycarbonylpyrrolidine
https://huagongshe.com/reaction/1029632
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Benzoate | HCID 517055 | — |
| Reactant | Tert-butyl (3R)-3-(methanesulfonyloxy)pyrrolidine-1-carboxylate | HCID 10934372 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (S)-3-benzoyloxy-1-t-butoxycarbonylpyrrolidine | HCID 15117240 | 100.2% |
Reaction Steps
To a solution of (R)-1-t-butoxycarbonyl-3-methanesulfonyloxypyrrolidine (20 g) in dimethyl sulfoxide (200 ml) was added sodium benzoate (22 g) under nitrogen. After stirring at 100° C. for 1 hour, the solution was taken up into a mixture of ethyl acetate and water. The organic layer was separated, and washed with water and brine successively. The dried solvent was evaporated to give (S)-3-benzoyloxy-1-t-butoxycarbonylpyrrolidine (22 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05102877 |
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| Source dataset | uspto-grants-1992_04 |
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| ORD ID | ord-e333c734f4d44231b34cde2e71aea707 |
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| Source note | uspto-grants-1992_04 |
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