反应详情

温度

40 °C

To a solution of (2S,4R)-4-(tert-butyldimethylsilyloxy)-1-(tert-butoxycarbonyl)-2-methanesulfonyloxymethylpyrrolidine (6.0 g) in tetrahydrofuran (60 ml) was added slowly lithium aluminum hydride (1.11 g) at 0° C. And then, the reaction mixture was allowed to warm to 40° C. and stirred for one hour. To the reaction mixture were added dropwise water (1.11 ml), 4N-aqueous sodium hydroxide (1.11 ml) and water (3.33 ml). The precipitate was filtered off, and the solvent was removed in vacuo to give (2R,4R)-4-(tert-butyldimethylsilyloxy)-1-(tert-butoxycarbonyl)-2-methylpyrrolidine (4.0 g).

1. filtrationThe precipitate was filtered off
2. customthe solvent was removed in vacuo