反应详情

To a solution of (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxy-2-methylpyrrolidine (1.92 g) and methanesulfonyl chloride (955 μl) in dichloromethane (30 ml) was added dropwise triethylamine (1.99 ml) at 0° C. After one hour, the reaction mixture was washed in turn with 1N-hydrochloric acid and brine and the organic layer was dried over magnesium sulfate. Evaporation of the solvent gave an oil, which was chromatographed on silica gel (200 ml) eluting with a mixture of hexane and ethyl acetate (1:1, V/V) to give (2R,4R)-1-(tert-butoxycarbonyl)-4-methanesulfonyloxy-2-methylpyrrolidine (2.49 g).

1. washthe reaction mixture was washed in turn with 1N-hydrochloric acid and brine
2. dry with materialthe organic layer was dried over magnesium sulfate
3. customEvaporation of the solvent
4. customgave an oil, which
5. customwas chromatographed on silica gel (200 ml)
6. washeluting with a mixture of hexane and ethyl acetate (1:1, V/V)