反应详情

To hydrazine hydrate (38.6 g) was added dropwise a solution of ethyl 2-(1-hydroxyethyl)acrylate (106 g) in ethanol (20 ml) at 0° C. After the addition, the reaction mixture was allowed to warm to room temperature and stirred for 4 hours at the same temperature. The resulting reaction mixture was chromatographed on silica gel (2.2 l) eluting in turn with chloroform and a mixture of chloroform and methanol (8:1→2:1→1:1, V/V) to give 4-(1-hydroxyethyl)-3-pyrazolidinone (68 g).

1. additionAfter the addition
2. customThe resulting reaction mixture
3. customwas chromatographed on silica gel (2.2 l)
4. washeluting in turn with chloroform
5. additiona mixture of chloroform and methanol (8:1→2:1→1:1, V/V)