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HRID1029774

反应详情

EQUATION

反应方程式

HRID 1029774 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)[C@@H]1O[C@H]1c1ccc(OC)cc1
HCID158607

methyl (2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylate

C11H12O4

结构：Nc1ccc(Cl)cc1S
HCID2737518

2-AMINO-5-CHLOROTHIOPHENOL

C6H6ClNS

PRODUCTS

生成物

1
结构：COc1ccc([C@@H]2Sc3cc(Cl)ccc3NC(=O)[C@@H]2O)cc1
HCID15593400

未命名化合物

PROCEDURE

实验过程

In the same way as in Example 1, the reaction between 2-amino-5-chlorothiophenol and methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate affords (+)-(2S,3S)-8-chloro-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepine-4-one. Melting point: 237°-241° C. [α]D20 =+91.9° (c=0.1; DMF).