反应详情

N,N'-Carbonyldiimidazole (0.66 g) is added to a solution of (R)-2-phenylpropionic acid (0.62 g) in dry dichloromethane (30 cc), cooled to +5° C. The mixture is stirred for 30 minutes at +5° C. and a solution of (3aR,7aR)-7,7-diphenyl-4-perhydroisoindolone hydrochloride (1.35 g) and triethylamine (0.57 cc) in dichloromethane (40 cc) is then added. The reaction mixture is stirred at 20° C. for 16 hours and then concentrated to dryness under reduced pressure (2.7 kPa). The residue is dissolved in ethyl acetate (100 cc) and the solution is washed with water (2×50 cc), dried over magnesium sulphate and filtered and the filtrate is concentrated to dryness under reduced pressure (4 kPa). The residue is chromatographed on a silica gel column (0.2-0.04 mm, diameter 2.8 cm, height 15 cm), eluting under a nitrogen pressure of 0.5 bar with a mixture of cyclohexane and ethyl acetate (60/40 by volume) and collecting 50 cc fractions. Fractions 4 to 8 are concentrated to dryness under reduced pressure (4 kPa) to give (3aR,7aR)-7,7-diphenyl-2-[(R)-2-phenylpropionyl]-4-perhydroisoindolone (1.4 g) in the form of a white meringue, the infrared spectrum of which is identical to that of the product from Example 68; [α]D20 =-278° (c=1, methanol).

1. temperaturecooled to +5° C
2. stirringThe reaction mixture is stirred at 20° C. for 16 hours
3. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)
4. dissolutionThe residue is dissolved in ethyl acetate (100 cc)
5. washthe solution is washed with water (2×50 cc)
6. dry with materialdried over magnesium sulphate
7. filtrationfiltered
8. concentrationthe filtrate is concentrated to dryness under reduced pressure (4 kPa)
9. customThe residue is chromatographed on a silica gel column (0.2-0.04 mm, diameter 2.8 cm, height 15 cm)
10. washeluting under a nitrogen pressure of 0.5 bar
11. additionwith a mixture of cyclohexane and ethyl acetate (60/40 by volume)
12. customcollecting 50 cc fractions
13. concentrationFractions 4 to 8 are concentrated to dryness under reduced pressure (4 kPa)