Ethanol → HCID 19821140, compound

HRID 1030002Notes

Reaction equation

HRID 1030002 reaction equation
C([O:9][C:10]1[CH:15]=[C:14]([NH:16][C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:13]([O:25][CH3:26])=[CH:12][C:11]=1[CH3:27])(=O)C1C=CC=CC=1.[OH-].[Na+].C(O)C>Cl>[CH3:27][C:11]1[CH:12]=[C:13]([O:25][CH3:26])[C:14]([NH:16][C:17](=[O:24])[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:15][C:10]=1[OH:9]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 19821153HCID 19821153, compound

Product 1

HCID 19821140HCID 19821140, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

3 g (8.3 mmol) of 2-methyl-4-methoxy-5-benzoylaminophenyl benzoate was added into the mixture of 50 ml of sodium hydroxide and 50 ml of ethanol and the solution was heated at 100° C. under reflux for 2.5 hours. 40 ml of IN hydrochloric acid was added to the reaction mixture and precipitates were filtered, washed with water and recrystallized from ethanol to give 1.2 g (4.6 mmol) of 2-methyl-4-methoxy-5-benzoylaminophenol in the form of pale yellow plate-like crystals. The yield was 78%.

Workup

  1. temperatureunder reflux for 2.5 hours
  2. customprecipitates
  3. filtrationwere filtered
  4. washwashed with water
  5. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-a1a95e4788ab4ec5ae0f370959ff46c1
Source dataset
uspto-grants-1992_04
Patent number
US05104414

Reaction notes

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