Sodium Bicarbonate → HCID 131717276, compound

HRID 1030056Notes

Reaction equation

S([O-])([O-])(=O)=O.[NH2:6][C:7]1[S:11][N:10]=[C:9]([C:12](=[N:35][O:36][CH2:37][CH:38]=[CH2:39])[C:13]([NH:15][CH:16]2[C:33](=[O:34])[N:18]3[C:19]([C:30]([OH:32])=[O:31])=[C:20]([CH2:23][N+:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:21][S:22][C@H:17]23)=[O:14])[N:8]=1.NC1SN=C(C(=NOCC=C)C(NC2C(=O)N3C([C:64]([OH:66])=[O:65])=C(C[N+]4C=CC=CC=4)CS[C@H]23)=O)N=1.C(=O)([O-])O.[Na+:78]>>[C:64]([NH:6][C:7]1[S:11][N:10]=[C:9]([C:12](=[N:35][O:36][CH2:37][CH:38]=[CH2:39])[C:13]([NH:15][CH:16]2[C:33](=[O:34])[N:18]3[C:19]([C:30]([O-:32])=[O:31])=[C:20]([CH2:23][N+:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH2:21][S:22][C@H:17]23)=[O:14])[N:8]=1)([O-:66])=[O:65].[Na+:78]

Participants

Reactant 2

HCID 516892Sodium Bicarbonate

HCID 131717271HCID 131717271, compound

Product 1

HCID 131717276HCID 131717276, compound

Procedure

Sodium 7-[2-(5-carboxylatoamino-1,2,4-thiadiazol-3-yl)-2-allyloxyiminoacetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylate (syn isomer) was prepared by reacting 7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-allyloxyiminoacetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylate hemisulfate (syn isomer((50 mg) and sodium hydrogencarbonate (15.3 mg) and detected according to a similar manner to that of Example 17.

Sources & evidence

ORD record: ord-5c29b757b2cf489c88764333c2c56441
Source dataset: uspto-grants-1992_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05104866

Reaction notes

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