Sodium Bicarbonate → HCID 131717276, compound

HRID 1030058Notes

Reaction equation

Cl.[NH2:2][C:3]1[S:7][N:6]=[C:5]([C:8](=[N:31][O:32][CH2:33][CH:34]=[CH2:35])[C:9]([NH:11][CH:12]2[C:29](=[O:30])[N:14]3[C:15]([C:26]([O-:28])=[O:27])=[C:16]([CH2:19][N+:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:17][S:18][C@H:13]23)=[O:10])[N:4]=1.[C:36](=O)([O-:38])[OH:37].[Na+:40]>>[C:36]([NH:2][C:3]1[S:7][N:6]=[C:5]([C:8](=[N:31][O:32][CH2:33][CH:34]=[CH2:35])[C:9]([NH:11][CH:12]2[C:29](=[O:30])[N:14]3[C:15]([C:26]([O-:28])=[O:27])=[C:16]([CH2:19][N+:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:17][S:18][C@H:13]23)=[O:10])[N:4]=1)([O-:38])=[O:37].[Na+:40]

Participants

Reactant 2

HCID 516892Sodium Bicarbonate

HCID 131717275HCID 131717275, compound

Product 1

HCID 131717276HCID 131717276, compound

Procedure

Sodium 7-[2-(5-carboxylatoamino-1,2,4-thiadiazol-3-yl)-2-allyloxyiminoacetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylate (syn isomer) was prepared by reacting 7-[2-(5-amino-1,2,4-thiadiazol-3yl)-2-allyloxyiminoacetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylate hydrochloride (syn isomer) (50 mg) and sodium hydrogencarbonate (15.6 mg) and detected according to a similar manner to that of Example 17.

Sources & evidence

ORD record: ord-66cbc9fc645b458fa564147297709764
Source dataset: uspto-grants-1992_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05104866

Reaction notes

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