Sodium Hydroxide → HCID 19821797, compound

HRID 1030064Notes

Reaction equation

HRID 1030064 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([Cl:11])[C:3]=1[N:12]1[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]=[CH:13]1.[OH-].[Na+]>Cl>[NH2:8][C:6]1[CH:5]=[C:4]([Cl:11])[C:3]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:20])([F:22])[F:21])[N:14]=[CH:13]2)=[C:2]([Cl:1])[CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19821802HCID 19821802, compound

Product 1

HCID 19821797HCID 19821797, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1-(2,6-Dichloro-4-nitrophenyl)-4-trifluoromethylpyrimidin-6-one (2.0 g) was added in one portion to a stirred suspension of stannous chloride (4.46 g) in concentrated aqueous hydrochloric acid (50 ml) at ambient temperature. After a period of 61/2 hours, the reaction mixture was poured into ice/water, made basic with aqueous sodium hydroxide solution, and extracted into ethyl acetate. The organic extracts were dried (magnesium sulphate), filtered, and evaporation of the solvent, under reduced pressure, gave 1-(4-amino-2,6-dichlorophenyl)-4-trifluoromethylpyrimidin-6-one as a yellow oil which solidified on standing (1.41 g). The compound showed:

Workup

  1. extractionextracted into ethyl acetate
  2. dry with materialThe organic extracts were dried (magnesium sulphate)
  3. filtrationfiltered
  4. customevaporation of the solvent

Sources & evidence

ORD record
ord-12c27f41e32a46ebbd00cee67c4fe167
Source dataset
uspto-grants-1992_04
Patent number
US05104878

Reaction notes

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