Ammonia → 3-chloro-4-(trifluoromethoxy)benzamide

HRID 1030089Notes

Reaction equation

HRID 1030089 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:15])([F:14])[F:13])[C:5](F)=[O:6].[NH3:16]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:15])([F:14])[F:13])[C:5]([NH2:16])=[O:6]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 198817533-Chloro-4-(trifluoromethoxy)benzoyl fluoride

Product 1

HCID 27738443-chloro-4-(trifluoromethoxy)benzamide

Procedure

242.5 g (1 mol) of 3-chloro-4-trifluoromethoxybenzoyl fluoride were allowed to drop into 500 ml of 25% strength by weight aqueous ammonia solution with ice cooling, then the mixture was stirred for 30 minutes and the precipitate which deposited was filtered off with suction. 227 g of product having a melting point of 98° C. were obtained. This corresponds to a crude yield of 95% of theory.

Workup

  1. filtrationthe precipitate which deposited was filtered off with suction
  2. customwere obtained

Sources & evidence

ORD record
ord-0f6fb60eb044448a853f41f0561712a2
Source dataset
uspto-grants-1992_04
Patent number
US05104879

Reaction notes

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