Sodium Hydroxide → 3-(3-Phenylpropyl)pyridine

HRID 1030093Notes

Reaction equation

HRID 1030093 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=O)[CH:2]=1.[OH-].[Na+].O.NN>C(O)COCCO>[C:11]1([CH2:10][CH2:9][CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 14330044HCID 14330044, compound

Product 1

HCID 745393-(3-Phenylpropyl)pyridine

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

Heat a mixture of 2-phenylethyl 3-pyridinyl ketone (19.5 g, 0.092M), NaOH (8.0 g), hydrazine hydrate (8 ml, 85% in H2O) and diethylene glycol (125 ml) to 240° C. for 4 hours.

Workup

  1. temperatureHeat

Sources & evidence

ORD record
ord-d06535ac81374380b840de9fbb1c74bc
Source dataset
uspto-grants-1992_04
Patent number
US05104876

Reaction notes

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