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HRID1030169

反应详情

EQUATION

反应方程式

HRID 1030169 的结构方程式

REACTANTS

反应物

3
结构：C=O
HCID712

Formaldehyde

CH2O

结构：[BH3-]C#N.[Na+]
HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

结构：COc1ccc(CSC[C@@H]2CCCN2)cc1
HCID57043207

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CSC[C@@H]2CCCN2C)cc1
HCID57048351

未命名化合物

收率 41.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

The procedure described in preparation 5-(4) was repeated, but using 2 g of (2S)-2-(4-methoxybenzylthio-methyl)pyrrolidine, 35% formalin and 848 mg of sodium cyanoborohydride in the presence of 44 ml of acetonitrile, to afford 883 mg of the title compound as an oil.

WORKUP

后处理

  1. customThe procedure described in preparation 5-(4)