反应详情

4-(2-Thiazolylimino)-2,3,6-trimethylphenol (0.60 g) was dissolved in 10 ml of tetrahydrofuran. To the solution was added a solution of 7.6 g of sodium hydrosulfite in 29 ml of water. The mixture was stirred at room temperature for 45 minutes and then extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated. Recrystallization of the crude product obtained from acetonitrile gave 0.56 g of the desired compound as colorless crystals.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with saturated aqueous sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. customRecrystallization of the crude product
6. customobtained from acetonitrile