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0 °C

The 2-(bromomethyl)quinoxaline (3.0 g, 13.4 mmol) was added portionwise to a stirring solution of methylamine (30%) in ethanol (100 mL) at 0° C. The reaction was stirred at 0° C. for 2 hours, concentrated, and partitioned between 10% aqueous potassium carbonate/ethyl acetate. The organic phase was dried (MgSO4), decolorized (charcoal) and concentrated. Purification was accomplished by eluting the sample through a short silica plug to yield 1.80 g (78%) of a brown oil.

1. concentrationconcentrated
2. custompartitioned between 10% aqueous potassium carbonate/ethyl acetate
3. dry with materialThe organic phase was dried (MgSO4)
4. concentrationconcentrated
5. customPurification
6. washby eluting the sample through a short silica plug