Sodium Iodide → N-[4-(3-Iodo-1-propylthio)phenyl]methanesulfonamide

Participants

Reaction Steps

A solution of N-[4-(3-chloro-1-propylthio)phenyl]methanesulfonamide (4.0 g, 0.014 mol) and sodium iodide (6.4 g 0.043 mol) in acetone (55 mL) was heated under reflux for 18 hours. The mixture was concentrated, taken up in EtOAc, washed with brine, 10% aqueous sodium bisulfite, brine, dried (MgSO4), and concentrated to give 4.8 g (91%) of product as an off-white and solid m.p. 59°-63° C.

Provenance & Evidence