反应详情

A solution of N-[4-(3-chloro-1-propylthio)phenyl]methanesulfonamide (4.0 g, 0.014 mol) and sodium iodide (6.4 g 0.043 mol) in acetone (55 mL) was heated under reflux for 18 hours. The mixture was concentrated, taken up in EtOAc, washed with brine, 10% aqueous sodium bisulfite, brine, dried (MgSO4), and concentrated to give 4.8 g (91%) of product as an off-white and solid m.p. 59°-63° C.

1. temperatureunder reflux for 18 hours
2. concentrationThe mixture was concentrated
3. washwashed with brine, 10% aqueous sodium bisulfite, brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated