Formaldehyde → HCID 10968376, compound

HRID 1030305Notes

Reaction equation

HRID 1030305 reaction equation
[C:1]1([C@@H:7]([NH:9][CH2:10][Si:11]([CH3:14])([CH3:13])[CH3:12])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:15]=[O:16]>C(O)CCC>[C:1]1([C@@H:7]([N:9]([CH2:10][Si:11]([CH3:13])([CH3:12])[CH3:14])[CH2:15][O:16][CH2:6][CH2:1][CH2:2][CH3:3])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 13526351HCID 13526351, compound

Product 1

HCID 10968376HCID 10968376, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

The title compound was prepared from (S)-(-)-N-1-phenylethyl-N-trimethylsilylmethylamine by reaction with n-butanol and aqueous formaldehyde following the procedure of Example 2 to give the crude acetal (85% pure) as a colourless oil (7.1 g, 80%) δC (CD2Cl2)-1.09 (SiMe3), 14.35, 20.16, 24.72, 67.38 (OBu), 19.57 (CMe), 40.30 (NCH2Si), 62.30 (CH), 84.73 (NCH2O), 127.01, 128.15, 128.51, 146.15 (Ph).

Sources & evidence

ORD record
ord-f367c87a673c474f93a70d2c00937dd8
Source dataset
uspto-grants-1992_04
Patent number
US05104989

Reaction notes

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