HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 19822279, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfolane | HCID 31347 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | HCID 19822173 | HCID 19822173 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | HCID 19822279 | HCID 19822279 | — |
Reaction Steps
The procedure described in Example 3 was repeated, but using 3.8 g of ethyl 3-[2-(6-acetoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)pyridin-5-yl]-2-chloropropionate (prepared as described in Preparation 38), 0.77 g of thiourea, 5.0 ml of sulfolane, 4.5 ml of ethylene glycol monomethyl ether, 1.5 ml of concentrated hydrochloric acid and 4.5 ml of water, to give the title compound, softening at 87°-94° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05104888 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-0ea6adce5cf64d49a229af4141e42c2e |
| Source note | uspto-grants-1992_04 |