Hydrochloric Acid → HCID 19822279, compound

HRID 1030358Notes

Reaction equation

HRID 1030358 reaction equation
C([O:4][C:5]1[C:6]([CH3:34])=[C:7]2[C:12](=[C:13]([CH3:16])[C:14]=1[CH3:15])[O:11][C:10]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH:27](Cl)[C:28](OCC)=[O:29])=[CH:22][N:21]=1)([CH3:17])[CH2:9][CH2:8]2)(=O)C.[NH2:35][C:36](N)=[S:37].S1(CCCC1)(=O)=[O:40].Cl>O.COCCO>[OH:4][C:5]1[C:6]([CH3:34])=[C:7]2[C:12](=[C:13]([CH3:16])[C:14]=1[CH3:15])[O:11][C:10]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH:27]3[S:37][C:36](=[O:40])[NH:35][C:28]3=[O:29])=[CH:22][N:21]=1)([CH3:17])[CH2:9][CH2:8]2

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2723790ThioureaHCID 19822173HCID 19822173, compound

Product 1

HCID 19822279HCID 19822279, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 80192-MethoxyethanolSolvent

Procedure

The procedure described in Example 3 was repeated, but using 3.8 g of ethyl 3-[2-(6-acetoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)pyridin-5-yl]-2-chloropropionate (prepared as described in Preparation 38), 0.77 g of thiourea, 5.0 ml of sulfolane, 4.5 ml of ethylene glycol monomethyl ether, 1.5 ml of concentrated hydrochloric acid and 4.5 ml of water, to give the title compound, softening at 87°-94° C.

Sources & evidence

ORD record
ord-0ea6adce5cf64d49a229af4141e42c2e
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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