Hydrochloric Acid → HCID 19822284, compound

HRID 1030359Notes

Reaction equation

HRID 1030359 reaction equation
C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:18])([CH3:17])[CH3:16])[O:11][C:10]([CH2:20][O:21][C:22]1[CH:23]=[C:24]([CH2:29][CH:30](Cl)[C:31]([O:33]CC)=O)[CH:25]=[CH:26][C:27]=1[CH3:28])([CH3:19])[CH2:9][C:8]2=[O:37])(=O)C.[NH2:38][C:39](N)=[S:40].S1(CCCC1)(=O)=[O:43].Cl>COCCO>[C:15]([C:14]1[CH:13]=[C:12]2[C:7]([C:8](=[O:37])[CH2:9][C:10]([CH2:20][O:21][C:22]3[CH:23]=[C:24]([CH:25]=[CH:26][C:27]=3[CH3:28])[CH2:29][CH:30]3[S:40][C:39](=[O:43])[NH:38][C:31]3=[O:33])([CH3:19])[O:11]2)=[CH:6][C:5]=1[OH:4])([CH3:17])([CH3:18])[CH3:16]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2723790ThioureaHCID 19822256HCID 19822256, compound

Product 1

HCID 19822284HCID 19822284, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

the procedure described in Example 3 was repeated, but using 2,4 g of ethyl 3-[3-(6-acetoxy-7-t-butyl-2-methyl-4-oxochroman-2-ylmethoxy) -4-methylphenyl]-2-chloropropionate (prepared as described in Preparation 42), 0.7 g of thiourea, 5 ml of sulfolane, 10 ml of 2N aqueous hydrochloric acid and 15 ml of ethylene glycol monomethyl ether, to give the title compound.

Sources & evidence

ORD record
ord-0789e6a2d9bb450592484f0bbc5f8d17
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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