Hydrochloric Acid → HCID 19822189, compound

Participants

Reaction Steps

The procedure described in Example 3 was repeated, but using 2.2 g of ethyl 3-[4-(6-acetoxy-2-hydroxy-5,7,8-trimethyl-4-oxochroman-2-ylmethoxy) phenyl]-2-chloropropionate (prepared as described in Preparation 45), 0.8 g of thiourea, 4.5 g of sulfolane, 70 ml of ethylene glycol monomethyl ether, 8 ml of water and 4 ml of 35% w/v aqueous hydrochloric acid, to give the title compound, melting at 249°-252° C.

Provenance & Evidence