Hydrochloric Acid → HCID 19822189, compound

HRID 1030360Notes

Reaction equation

HRID 1030360 reaction equation
C([O:4][C:5]1[C:6]([CH3:35])=[C:7]2[C:12](=[C:13]([CH3:16])[C:14]=1[CH3:15])[O:11][C:10]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH:27](Cl)[C:28](OCC)=[O:29])=[CH:22][CH:21]=1)(O)[CH2:9][C:8]2=[O:34])(=O)C.[NH2:36][C:37](N)=[S:38].S1(CCCC1)(=O)=[O:41].Cl>O.COCCO>[OH:4][C:5]1[C:6]([CH3:35])=[C:7]2[C:12](=[C:13]([CH3:16])[C:14]=1[CH3:15])[O:11][CH:10]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH:27]3[S:38][C:37](=[O:41])[NH:36][C:28]3=[O:29])=[CH:22][CH:21]=1)[CH2:9][C:8]2=[O:34]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2723790ThioureaHCID 19822236HCID 19822236, compound

Product 1

HCID 19822189HCID 19822189, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 80192-MethoxyethanolSolvent

Procedure

The procedure described in Example 3 was repeated, but using 2.2 g of ethyl 3-[4-(6-acetoxy-2-hydroxy-5,7,8-trimethyl-4-oxochroman-2-ylmethoxy) phenyl]-2-chloropropionate (prepared as described in Preparation 45), 0.8 g of thiourea, 4.5 g of sulfolane, 70 ml of ethylene glycol monomethyl ether, 8 ml of water and 4 ml of 35% w/v aqueous hydrochloric acid, to give the title compound, melting at 249°-252° C.

Sources & evidence

ORD record
ord-0e3cbdd4c1844490a2417cf838cf9e19
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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