Pyridine → HCID 88491487, compound

HRID 1030366Notes

Reaction equation

HRID 1030366 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([CH3:19])([CH3:18])[CH2:13][C:14]([CH3:17])([CH3:16])[CH3:15])[O:8][C:7]([CH2:21][O:22][C:23]1[CH:36]=[CH:35][C:26]([CH2:27][CH:28]3[S:32][C:31](=[O:33])[NH:30][C:29]3=[O:34])=[CH:25][CH:24]=1)([CH3:20])[CH2:6][C:5]2=O.Cl.[NH2:39][OH:40].N1C=CC=CC=1>CO>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([CH3:19])([CH3:18])[CH2:13][C:14]([CH3:16])([CH3:17])[CH3:15])[O:8][C:7]([CH2:21][O:22][C:23]1[CH:24]=[CH:25][C:26]([CH2:27][CH:28]3[S:32][C:31](=[O:33])[NH:30][C:29]3=[O:34])=[CH:35][CH:36]=1)([CH3:20])[CH2:6]/[C:5]/2=[N:39]\[OH:40]

Participants

5

Reactant 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 19822191HCID 19822191, compound

Product 1

HCID 88491487HCID 88491487, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The procedure described in Example 13 was repeated, but using 1.0 g of 5-{4-[6-hydroxy-2-methyl-4-oxo-7-(1,1,3,3-tetramethylbutyl)chroman -2-ylmethoxy]benzyl}thiazolidine-2,4-dione (prepared as described in Example 7), 0.26 g of hydroxylamine hydrochloride, 0.3 g of pyridine and 10 ml of methanol, to give the title compound as a white powder, softening at 115°-120° C.

Sources & evidence

ORD record
ord-99b2429f350c40819ebcf4c239d7da25
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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