HuagongsheHuagongshe Chemistry Print Report · For research reference only
Troglitazone → t-Butyl alpha-{5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidin-3-yl}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Troglitazone | HCID 5591 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | t-Butyl alpha-{5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidin-3-yl}acetate | HCID 19822185 | — |
Reaction Steps
Following the procedure described in Example 44, 1 g of 5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]thiazolidine-2,4-dione [prepared as described in Example 27(b)], 0.47 g of anhydrous potassium carbonate, 0.93 g of t-butyl bromoacetate and 8 ml of acetone gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05104888 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-85e83aa784684da7990e25ca7fa649d3 |
| Source note | uspto-grants-1992_04 |