HRID1030382

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2

HCID5591

Troglitazone

C24H27NO5S

HCID11430

Potassium Carbonate

CK2O3

HCID79177

Acetic acid, bromo-, 1,1-dimethylethyl ester

C6H11BrO2

PRODUCTS

生成物

结构：Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)N(CC(=O)OC(C)(C)C)C3=O)cc1)O2

HCID19822185

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Following the procedure described in Example 44, 1 g of 5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]thiazolidine-2,4-dione [prepared as described in Example 27(b)], 0.47 g of anhydrous potassium carbonate, 0.93 g of t-butyl bromoacetate and 8 ml of acetone gave the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-85e83aa784684da7990e25ca7fa649d3
来源数据集: uspto-grants-1992_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05104888
来源说明: uspto-grants-1992_04

反应 SMILES

[OH:1][C:2]1[C:3]([CH3:31])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH2:15][O:16][C:17]1[CH:30]=[CH:29][C:20]([CH2:21][CH:22]3[S:26][C:25](=[O:27])[NH:24][C:23]3=[O:28])=[CH:19][CH:18]=1)([CH3:14])[CH2:6][CH2:5]2.C(=O)([O-])[O-].[K+].[K+].Br[CH2:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41]>CC(C)=O>[OH:1][C:2]1[C:3]([CH3:31])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH2:15][O:16][C:17]1[CH:30]=[CH:29][C:20]([CH2:21][CH:22]3[S:26][C:25](=[O:27])[N:24]([CH2:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[C:23]3=[O:28])=[CH:19][CH:18]=1)([CH3:14])[CH2:6][CH2:5]2