Hydrochloric Acid → HCID 19822275, compound

HRID 1030390Notes

Reaction equation

HRID 1030390 reaction equation
C([O:5][C:6]([CH2:8][O:9][C:10]1[C:11]([CH3:48])=[C:12]2[C:17](=[C:18]([CH3:21])[C:19]=1[CH3:20])[O:16][C:15]([CH2:23][O:24][C:25]1[CH:46]=[CH:45][C:28]([CH2:29][CH:30]3[S:34][C:33](=[O:35])[N:32]([CH2:36][C:37]([O:39]C(C)(C)C)=[O:38])[C:31]3=[O:44])=[CH:27][CH:26]=1)([CH3:22])[CH2:14][C:13]2=[O:47])=[O:7])(C)(C)C.Cl>O1CCOCC1>[C:6]([CH2:8][O:9][C:10]1[C:11]([CH3:48])=[C:12]2[C:17](=[C:18]([CH3:21])[C:19]=1[CH3:20])[O:16][C:15]([CH2:23][O:24][C:25]1[CH:46]=[CH:45][C:28]([CH2:29][CH:30]3[S:34][C:33](=[O:35])[N:32]([CH2:36][C:37]([OH:39])=[O:38])[C:31]3=[O:44])=[CH:27][CH:26]=1)([CH3:22])[CH2:14][C:13]2=[O:47])([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19822186HCID 19822186, compound

Product 1

HCID 19822275HCID 19822275, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 570 mg of t-butyl α-{5-[4-(6-t-butoxycarbonylmethoxy-2,5,7,8-tetramethyl-4-oxochroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidin3-yl}acetate (prepared as described in Example 51) and 6 ml of a 4N dioxane solution of hydrogen chloride was treated in the same manner described in Example 61, to give the title compound as a pale yellow powder, softening at 80°-85° C.

Workup

  1. additionwas treated in the same manner

Sources & evidence

ORD record
ord-8a0c7641a4d2425ab486450f0ba6e5fb
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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