HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 3-[4-(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)phenyl]-2-chloro-2-methylpropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Methacrylate | HCID 7343 | — |
| Reactant | HCID 9951222 | HCID 9951222 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 3-[4-(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)phenyl]-2-chloro-2-methylpropionate | HCID 19822192 | — |
Reaction Steps
Following the same procedure as described in Preparation 18, 2 g of 6-acetoxy-2-(4-aminophenoxymethyl)-2,5,7,8-tetramethylchroman (prepared as described in Preparation 50), 25 ml of acetone, 3 ml of 35% w/v aqueous hydrochloric acid, 0.7 g of sodium nitrite, 1 ml of water, 8 g of ethyl methacrylate and 0.2 g of cuprous oxide were reacted, to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05104888 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-fe65d0362cf04dcb8bcb53d794c0cb86 |
| Source note | uspto-grants-1992_04 |