反应详情

To a mixture of 30 g. potassium carbonate, 15 g. 1,2,4-triazole and 250 ml acetonitrile at 40° C. was added a solution of 45 g. 3,4-dihydro-2-bromo-1(2H)-naphthalenone in 150 ml acetonitrile. The mixture was allowed to react for 5 hours at 40° C. and then at reflux temperature for 2 hours. The solid was removed by filtration and the filtrate concentrated to dryness leaving a solid residue. This was dissolved in dichloromethane and washed twice with water. The organic extract was dried over sodium sulfate and evaporated to give 42 grams of product having a melting point of 96°-98° C.

1. additionTo a mixture of 30 g
2. customto react for 5 hours at 40° C.
3. temperatureat reflux temperature for 2 hours
4. customThe solid was removed by filtration
5. concentrationthe filtrate concentrated to dryness
6. customleaving a solid residue
7. washwashed twice with water
8. extractionThe organic extract
9. dry with materialwas dried over sodium sulfate
10. customevaporated