HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Ethyl 6-acetoxymethylnicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl 6-methyl-1-oxo-1lambda~5~-pyridine-3-carboxylate | HCID 15045502 | — |
| Product | Ethyl 6-acetoxymethylnicotinate | HCID 15045503 | 59.2% |
Reaction Steps
A mixture of 13.7 g of 5-ethoxycarbonyl-2-methyl-pyridine-1-oxide and 15 g of acetic anhydride was stirred under reflux. Excess acetic anhydride was removed under a reduced pressure, and the residue was purified by distillation under a reduced pressure (110° C./0.1 mmHg) to obtain 10.0 g of ethyl 6-acetoxymethylnicotinate. ##STR7##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05106859 |
| Source dataset | uspto-grants-1992_04 |
| ORD ID | ord-f82664c3b79d43438b9e0c0700f733fd |
| Source note | uspto-grants-1992_04 |