Hydrochloric Acid → HCID 131716989, compound

HRID 1030646Notes

Reaction equation

HRID 1030646 reaction equation
C(OC[C:5]([CH2:27]OCC)([OH:26])[CH:6]([NH:18]C(OC(C)(C)C)=O)[CH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1)C.[ClH:31]>>[ClH:31].[NH2:18][C@H:6]1[CH2:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][C:9]=2[C@H:27]([Cl:31])[C@@H:5]1[OH:26]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67865966HCID 67865966, compound

Product 1

HCID 131716989HCID 131716989, compound

Conditions

Temperature
100 °C

Procedure

A suspension of α,α-diethoxymethyl-β-tert-butoxycarbonylamino-1-naphthalenepropanol (250 mg), isomer A was stirred in 37% aqueous hydrochloric acid at 0° C. for 1 hour. The resulting emulsion was then stirred at 100° C. for 3 minutes and the flask was immediately cooled in an ice water bath. The precipitate was filtered, washed with water and dried in vacuo to yield the title compound (152 mg) as a white solid.

Workup

  1. temperaturethe flask was immediately cooled in an ice water bath
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-8754dc908324436a8faf1dc61626d073
Source dataset
uspto-grants-1992_04
Patent number
US05106861

Reaction notes

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