反应详情

To 120 ml of acetonitrile were added 1.50 g (3.62 mmols) of 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl) adenine, 946 mg (1.84 mmol) of N,N'-diheptyl-4,4'-bipyridinium dibromide, 1.13 g of 10% palladium-carbon (water content, 50%) and 2.5 ml of triethylamine. The mixture was stirred for 2 hours at room temperature in a hydrogen atmosphere. The analysis by HPLC reveals that the raw material disappeared and 5'-O-acetyl-2',3'-didehydro-2',3'-dideoxyadenosine (85), 5'-O-acetyl-2',3'-dideoxyadenosine (11%) and 2',5'-di-O-acetyl-3'-deoxyadenosine (3%) were formed.