反应详情

In 50 ml of chloroform was dissolved 1.47 g of 2-(2-dimethylaminobenzylthio)quinoxaline. To the chilled solution kept at --10° C. was portionwise added 1.54 g of m-chloroperbenzoic acid (purity: 80%). To the reaction liquid were washed successively with saturated aqueous NaHCO3 solution, water and saturated aqueous sodium chloride solution, and dried over sodium sulfate. The sodium sulfate was then removed by filtration, and the solvent was evaporated under reduced pressure from the filtrate. The residue was purified by silica gel column chromatography (hexane/acetone) to give 330 mg of 2-(2-dimethylaminobenzylsulfinyl)quinoxaline as a yellow powder, m.p. 114°-115° C.

1. custom-10° C.
2. customTo the reaction liquid
3. washwere washed successively with saturated aqueous NaHCO3 solution, water and saturated aqueous sodium chloride solution
4. dry with materialdried over sodium sulfate
5. customThe sodium sulfate was then removed by filtration
6. customthe solvent was evaporated under reduced pressure from the filtrate
7. customThe residue was purified by silica gel column chromatography (hexane/acetone)