HCID 19025404, compound → HCID 19025421, compound

HRID 1030989Notes

Reaction equation

HRID 1030989 reaction equation
[CH2:1]([N:3]([C:7]1[CH:12]=[C:11]([F:13])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:8]=1[F:17])[C:4](=O)[CH3:5])[CH3:2]>O1CCCC1>[CH2:4]([N:3]([CH2:1][CH3:2])[C:7]1[CH:12]=[C:11]([F:13])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:8]=1[F:17])[CH3:5]

Participants

3

Reactant 1

HCID 19025404HCID 19025404, compound

Product 1

HCID 19025421HCID 19025421, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Following procedures similar to those employed in Step E of this Example, the reaction of 4.2 g (0.017 mole) of N-ethyl-N-(2,5-difluoro-4-nitrophenyl)acetamide with 5.1 ml of a 10M borane dimethyl sulfide complex in tetrahydrofuran in 100 ml of dry tetrahydrofuran yielded 3.6 g of N,N-diethyl-2,5-difluoro-4-nitroaniline. The nmr spectrum was consistent with the proposed structure.

Sources & evidence

ORD record
ord-3034badcf11e4e76a7b7a92d4a7fe4f5
Source dataset
uspto-grants-1992_04
Patent number
US05108486

Reaction notes

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