HCID 15617260, compound → HCID 15617261, compound

HRID 1031002Notes

Reaction equation

HRID 1031002 reaction equation
[Br:1][CH2:2][C:3]1[C:4]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:5]([S:9]([NH:12]C(C)(C)C)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1>FC(F)(F)C(O)=O>[Br:1][CH2:2][C:3]1[C:4]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:5]([S:9]([NH2:12])(=[O:10])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 15617260HCID 15617260, compound

Product 1

HCID 15617261HCID 15617261, compoundYield 80.5%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 5.7 g of 3-bromomethyl-2-carboethoxy-N-(1,1-dimethylethyl)benzenesulfonamide in 60 mL of trifluoroacetic acid was stirred at room temperature for 16 hours. Concentration provided a viscous oil which was triturated with n-butyl chloride. The solids were collected to yield 3.91 g of a white solid, m.p. 138°-140° C.

Workup

  1. concentrationConcentration
  2. customprovided a viscous oil which
  3. customwas triturated with n-butyl chloride
  4. customThe solids were collected

Sources & evidence

ORD record
ord-77156f315f74444f8107f13d6eefa3ba
Source dataset
uspto-grants-1992_04
Patent number
US05108487

Reaction notes

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