Hydrochloric Acid → HCID 22402961, compound

HRID 1031019Notes

Reaction equation

HRID 1031019 reaction equation
[CH2:1]([N:3]1[C:7]2=[CH:8][CH:9]=[C:10]([C:16]([O:18]C)=[O:17])[C:11]([C:12]([O:14]C)=[O:13])=[C:6]2[N:5]=[C:4]1[CH3:20])[CH3:2].[OH-].[Na+].Cl>CO>[CH2:1]([N:3]1[C:7]2=[CH:8][CH:9]=[C:10]([C:16]([OH:18])=[O:17])[C:11]([C:12]([OH:14])=[O:13])=[C:6]2[N:5]=[C:4]1[CH3:20])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22402939HCID 22402939, compound

Product 1

HCID 22402961HCID 22402961, compoundYield 85.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of dimethyl 1-ethyl-2-methyl-4,5-benzimidazoledicarboxylate (5.30 g, 19.2 mmol), methanol and 5N sodium hydroxide (30 mL, I50 mmol) is stirred for 4 hours at 100° C., cooled, acidified with hydrochloric acid and filtered to give the title product as a lemon yellow powder (4.07 g, 85.5%), identified by 1HNMR spectral analysis.

Workup

  1. temperaturecooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-4abcf3f08f2044cab8dd4c0553e45a48
Source dataset
uspto-grants-1992_04
Patent number
US05108485

Reaction notes

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