Carbonate Ion → 3,7-Diethyl-1-(6-hydroxy-6-methylheptyl)-xanthine

HRID 1031076Notes

Reaction equation

HRID 1031076 reaction equation
[CH2:1]([N:3]1[C:11]2[N:10]=[CH:9][N:8]([CH2:12][CH3:13])[C:7]=2[C:6](=[O:14])[NH:5][C:4]1=[O:15])[CH3:2].C(=O)([O-])[O-].Br[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([OH:29])([CH3:28])[CH3:27]>CN(C)C=O>[CH2:1]([N:3]1[C:11]2[N:10]=[CH:9][N:8]([CH2:12][CH3:13])[C:7]=2[C:6](=[O:14])[N:5]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([OH:29])([CH3:28])[CH3:27])[C:4]1=[O:15])[CH3:2]

Participants

5

Reactant 3

HCID 19660Carbonate IonHCID 3507183,7-DiethylxanthineHCID 234396987-Bromo-2-methylheptan-2-ol

Product 1

HCID 98625993,7-Diethyl-1-(6-hydroxy-6-methylheptyl)-xanthine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6.2 g of 3,7-diethylxanthine, 4.1 g of ptassium carbonate, and 6.6 g of 1-bromo-6-hydroxy-6-methylheptane are stirred in 100 ml of dimethylformamide at 120° C. for 18 hours. The mixture is filtered hot with suction, the filtrate is concentrated under recuced pressure final recrystallization from diisopropylether with addition of petroleum ether.

Workup

  1. filtrationThe mixture is filtered hot with suction
  2. concentrationthe filtrate is concentrated under recuced pressure final
  3. customrecrystallization from diisopropylether
  4. additionwith addition of petroleum ether

Sources & evidence

ORD record
ord-99b567231b784caa8db1791373953f7c
Source dataset
uspto-grants-1992_04
Patent number
US05109003

Reaction notes

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