Water → HCID 67796137, compound

HRID 1031160Notes

Reaction equation

HRID 1031160 reaction equation
Br[CH2:2][C:3]1[CH:7]=[N:6][N:5]([C:8]2[C:13]([Cl:14])=[CH:12][C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=2[Cl:19])[N:4]=1.[C-:20]#[N:21].[K+].O>CS(C)=O>[Cl:19][C:9]1[CH:10]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:12]=[C:13]([Cl:14])[C:8]=1[N:5]1[N:4]=[C:3]([CH2:2][C:20]#[N:21])[CH:7]=[N:6]1

Participants

5

Reactant 3

HCID 962WaterHCID 9032Potassium CyanideHCID 19778339HCID 19778339, compound

Product 1

HCID 67796137HCID 67796137, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

4-Bromomethyl-2-(2,6-dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazole, prepared as in EP No. 350 237, was treated with potassium cyanide in dimethyl sulphoxide at room temperature for two hours. The mixture was added to water and extracted with diethyl ether. The extract was worked up to give crude 2-(2,6-dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-ylacetonitrile. In a similar manner to Example 6, this compound was converted to 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-[(1H-imidazol-2-yl)methyl]-2H-1,2,3-triazole,. (Compound 29a).

Workup

  1. extractionextracted with diethyl ether

Sources & evidence

ORD record
ord-1b55a21c35084343b717cb79fbe5fab3
Source dataset
uspto-grants-1992_04
Patent number
US05109012

Reaction notes

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