Diisopropyl Ether → HCID 19812269, compound

HRID 1031204Notes

Reaction equation

HRID 1031204 reaction equation
[C:1](#[N:5])[CH2:2][C:3]#[N:4].[N:6]([O-:8])=O.[Na+].Br[C:11]([CH3:18])([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13].C(OC(C)C)(C)C>C(#N)C.O.C(O)(=O)C>[CH2:15]([O:14][C:12]([C:11]([CH3:18])([O:8][N:6]=[C:2]([C:1]#[N:5])[C:3]#[N:4])[CH3:17])=[O:13])[CH3:16]

Participants

8

Reactant 4

HCID 7914Diisopropyl EtherHCID 8010MalononitrileHCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 23668193Sodium Nitrite

Product 1

HCID 19812269HCID 19812269, compoundYield 100.6%

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

To a solution of malononitrile (300 g) and acetic acid (54.6 g) in acetonitrile (2.1 l) was added sodium nitrite (313 g) at 60°-65° C. After being stirred at the same temperature for an hour, ethyl 2-bromo-2-methylpropanoate (797 g) was added to the mixture at 65° C. After being refluxed for five hours, the mixture was cooled to the ambient temperature and allowed to stand overnight. The resulting mixture was poured into a mixture of water (4.2 l) and diisopropyl ether (4.2 l). The separated organic layer was washed with water and brine, dried over magnesium sulfate and evaporated under reduced pressure to give 2-(1-ethoxycarbonyl-1-methylethoxyimino)propanedinitrile (860 g).

Workup

  1. temperatureAfter being refluxed for five hours
  2. washThe separated organic layer was washed with water and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-c19199aaccd04d1ba1acc144d913cf6a
Source dataset
uspto-grants-1992_04
Patent number
US05108997

Reaction notes

Loading…