Hydrochloric Acid → HCID 14585930, compound

HRID 1031215Notes

Reaction equation

HRID 1031215 reaction equation
[C:1]([CH2:3][CH2:4][NH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:17]#[N:18])#[N:2].[ClH:19]>C(O)(=O)C>[ClH:19].[ClH:19].[ClH:19].[ClH:19].[NH2:18][CH2:17][CH2:16][CH2:15][NH:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3][CH2:1][NH2:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23302080HCID 23302080, compound

Product 1

HCID 14585930HCID 14585930, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Combine 14.4 g (0.057 mol) of the product of Step A, 200 ml of acetic acid, 30 ml of conc. HCl, and 1.2 g PtO 2 and treat the mixture with H2 at 45 lbs/in2 in a shaker flask until H2 is no longer being reacted. Filter the mixture and remove the solvent at reduced pressure. 22.5 g of the title compound is obtained after purification. (Rf is 0.17 for TLC on silica gel developed with 40% conc. ammonia/methanol).

Workup

  1. customis no longer being reacted
  2. filtrationFilter the mixture
  3. customremove the solvent at reduced pressure

Sources & evidence

ORD record
ord-5a039a298ee048e2b18dafd7bc58b5da
Source dataset
uspto-grants-1992_04
Patent number
US05109024

Reaction notes

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